Abstract:
Biofluid mechanics play a major role in the cardiovascular system and blood as a whole, therefore, it may help in detecting and designing a treatment for some blood related diseases and understanding them better. The aim of this thesis is to study the trajectories of nanoparticles during magnetic drug targeting for treatment of cancer and cardiovascular disorders in a fractionalized blood flow. Nanoparticle (NP)-based drug delivery systems have shown many advantages in cancer and cardiovascular treatment. In the present study, magnetic drug targeting which is one of the major drug delivery when treating cancer and cardiovascular diseases was used due to its noninvasiveness, high targeting efficiency and minimized toxic side effects on healthy cells and tissues. Firstly the impact of Reynolds number, pulsatile frequency, magnetic field strength and the Darcy number in a fractionalized blood flow through a permeable vessel was analyzed. We assumed that the blood vessel segment is a rigid cylindrical tube and blood along with magnetic particle flowing through the vessel shows Newtonian behaviour with a constant viscosity. Lastly, we have used a two phase model where the radius of the micro vessel is divided into two parts. The flow nature at the clear region is defined by non-Newtonian Jeffrey fluid and the peripheral region is defined by Newtonian fluid. The wall of the micro vessel is considered as permeable. We have analyzed and discussed the effects of the time relaxation to
retardation ratio, Jeffrey parameter, pulsatile frequency, magnetic field strength and the Darcy number on the trajectories of the drug carrier during magnetic drug targeting. The fractional parameter boost up the motion of radial motion of the drug carrier particles, while restricting the axial motion of the carrier particles as observed in the study through graphs plotted with fractional parameter as a contributing factor. All parameters except the pulsatile frequency accelerated the radial motion of the drug carrier particles as observed in the results. The theory developed can be used to determine the optimum size of the carrier particle for treating a tumor with a given size and location within the body.
