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Magnetic drug targeting phenomena during non- Newtonian flow in the microvessel with time- Fractional derivative

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dc.contributor.supervisor Shaw, Sachin
dc.contributor.author Habtamu Bayissa, Yadeta
dc.date.accessioned 2026-03-16T09:43:30Z
dc.date.available 2026-03-16T09:43:30Z
dc.date.issued 2025-06
dc.identifier.citation Yadeta,H,B (2025) Magnetic drug targeting phenomena during non- Newtonian flow in the microvessel with time- Fractional derivative, Dissertation, Botswana International University of Science and Technology: Palapye en_US
dc.identifier.uri https://repository.biust.ac.bw/handle/123456789/731
dc.description Dissertation (PhD in Mathematics)---Botswana International University of Science and Technology, 2025 en_US
dc.description.abstract Cancer and cardiovascular disease are the leading causes of death worldwide incurring substantial medical costs and care and become a potential barrier to average life expectancy. Several treatment options available have considerable side effects and often are not sufficient for curative treatment. Most challenges include targeting non-specifically, poor pharmacokinetic characteristics drugs arising from poor solubility, stability, and toxicity, inefficacy and limited bio-distribution. Recently, with the advancement of nanotechnology, treatment options such as magnetic drug targeting (MDT) through the application of magnetic nanoparticles (MNPs) treatment have significantly changed the paradigm of cancer treatment due to minimum side effects and high efficacy. This research aims at theoretical analysis to examine the efficacy of the accumulation of drug carrier magnetic nanoparticles influenced by biophysical parameters near the diseased region during magnetic drug targeting. In this study, the time fractional derivatives of blood flow and factors governing the transport of drug carrier nanoparticles such as particle – particle interaction, Saffman uplift force, size and shape of carrier particles, permeability of the vessel, magnetic and viscous forces are considered. The conclusion drawn from the study shows that spherical shaped drugs carrying magnetic nanoparticles are more prominent to be targeted to the tumor region than other non-spherical shaped drugs carrying magnetic nanoparticles. Capture efficiency of the drug-carrier particles is improved with increase in the magnetization, and radius of carrier particles as both increase the magnetic force among the magnet and Drug-carrier particles. A decrease in Darcy number, Reynolds number, and tumor magnet distance decreases the total volume fraction of nanoparticles. Total volume fraction of magnetic nanoparticles decreases with increase in pulsatile frequency, Casson parameter and Hematocrit parameter. The velocity of blood and velocity of magnetic nanoparticles are boosted with enhancement in the Darcy number and Jeffrey fluid parameter, which shows an important application to the therapy of atherosclerosis. The flow resistance increases with an increase in stenosis height and Hartman number. The present study will help biomedical engineers and nanomedicine researchers develop magnetic devices and the next generation of drug carrier particles to treat cancerous tumors. en_US
dc.publisher BIUST en_US
dc.subject Magnetic drug targeting en_US
dc.subject Fractional derivative en_US
dc.subject Drug – carrier particles en_US
dc.subject Magnetic nanoparticles en_US
dc.subject Tumor en_US
dc.title Magnetic drug targeting phenomena during non- Newtonian flow in the microvessel with time- Fractional derivative en_US
dc.description.level phd en_US
dc.description.accessibility unrestricted en_US
dc.description.department mss en_US


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