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Metallo-Drugs as promising antibacterial agents and their modes of action

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dc.contributor.author Nareetsile, Florence
dc.contributor.author Matshwele, James T.P
dc.contributor.author Odisitse, Sebusi
dc.date.accessioned 2022-09-06T08:44:21Z
dc.date.available 2022-09-06T08:44:21Z
dc.date.issued 2022-05
dc.identifier.citation Nareetsile, F., Matshwele, J. P., Odisitse, S. (2022) Metallo-drugs as promising antibacterial agents and their modes of action. Journal of Medicinal and Chemical Sciences, 5(6), 1109-1131. doi: 10.26655/JMCHEMSCI.2022.6.24 en_US
dc.identifier.issn 26514702
dc.identifier.uri http://repository.biust.ac.bw/handle/123456789/482
dc.description.abstract Antibiotic resistance has been a growing worldwide public health issue. The World Health Organization (WHO) has stated that the search for new antibiotics is slow, while antibiotic resistance is growing. WHO has also declared that antibiotic resistance is one of the top 10 global public health threats facing humanity in the 21st century. Therefore, this review discusses the potential of metal-based drugs as antibacterial agents from the period of the early 2000s to date. The review reveals that a lot of preliminary work has been done to assess these as potential drugs. However, their mode of action is faintly described. Furthermore, a few examples of metal-based drugs assessed for their modes of action are described. These compounds are ideal as they have been observed to work with one or more modes of action and they are also able to induce or increase activity of free organic compounds once bound to the metal. Nonetheless, more studies are needed to understand the modes of action of other transition metal compounds. en_US
dc.description.sponsorship The authors would like to extend their gratitude to Botswana International University of Science and Technology for the research funding. en_US
dc.language.iso en en_US
dc.publisher Sami Publishing Company en_US
dc.subject Antibacterial en_US
dc.subject Medicinal chemistry en_US
dc.subject Metallo-drugs en_US
dc.subject Organometallic en_US
dc.subject Transition metal complex en_US
dc.title Metallo-Drugs as promising antibacterial agents and their modes of action en_US
dc.description.level phd en_US
dc.description.accessibility unrestricted en_US
dc.description.department cfs en_US


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