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Neuronal firing and DNA dynamics in a neural network

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dc.contributor.author Etémé, Armand Sylvin
dc.contributor.author Tabi, Conrad Bertrand
dc.contributor.author Ateba, Jean Felix Beyala
dc.contributor.author Ekobena, Henri Paul Fouda
dc.contributor.author Mohamadou, Alidou
dc.contributor.author Kofane, Timoléon Crepin
dc.date.accessioned 2022-05-04T09:59:13Z
dc.date.available 2022-05-04T09:59:13Z
dc.date.issued 2018-12-18
dc.identifier.citation Eteme, A. et.al. (2018) Neuronal firing and DNA dynamics in a neural network. Journal of Physics Communications, 2, https://doi.org/10.1088/2399-6528/aaf3f7. en_US
dc.identifier.issn 2399-6528
dc.identifier.uri http://repository.biust.ac.bw/handle/123456789/440
dc.description.abstract We study the mutual effects of neuronal electrical activity and DNA dynamics in a network of electrically coupled neurons with nearest neighbors communication. For that we develop by means of the coupling function method, a mathematical DNA-neuron model that can be considered as an extension of the simplified Hodgkin-Huxley models. Numerically, we explore the biological properties of the model with emphasis on local phase transitions and synchronous neural activity. Our results suggest that firing and coherent behavior of neural network are controlled by DNA dynamics. Conversely, neuronal activity induces DNA electrochemical denaturation. As a result, we expect that the prominent DNA-neuron model would be worth in controlling gene expression and neurodegen-erative diseases in the sensory thalamus. en_US
dc.language.iso en en_US
dc.publisher IOP Publishing Ltd en_US
dc.subject DNA en_US
dc.subject Neural network en_US
dc.subject Neuronal firing en_US
dc.subject Synchronization en_US
dc.subject DNA denaturation en_US
dc.title Neuronal firing and DNA dynamics in a neural network en_US
dc.description.level phd en_US
dc.description.accessibility unrestricted en_US
dc.description.department paa en_US


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