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Synthesis of mixed ligand ruthenium (II/III) complexes and their antibacterial evaluation on drug-resistant bacterial organisms

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dc.contributor.author Matshwele, James T. P.
dc.contributor.author Nareetsile, Florence
dc.contributor.author Mapolelo, Daphne
dc.contributor.author Matshameko, Pearl
dc.contributor.author Leteane, Melvin
dc.contributor.author Nkwe, David O.
dc.contributor.author Odisitse, Sebusi
dc.date.accessioned 2021-10-27T13:05:48Z
dc.date.available 2021-10-27T13:05:48Z
dc.date.issued 2020-03-19
dc.identifier.citation Matshwele,J. et al. (2020) Synthesis of mixed ligand ruthenium (II/III) complexes and their antibacterial evaluation on drug-resistant bacterial organisms. Journal of Chemistry, 2020,2150419, https://doi.org/10.1155/2020/2150419 en_US
dc.identifier.issn 20909071
dc.identifier.uri http://repository.biust.ac.bw/handle/123456789/373
dc.description.abstract The potential antimicrobial properties of a tridentate polypyridyl ligand 4-butoxy-N,N-bis(pyridin-2-ylmethyl)aniline (BUT) 1 and its corresponding mixed ligand ruthenium complexes were investigated on drug-resistant and non-drug-resistant bacterial species. The ligand and its complexes were synthesized and successfully characterized by 1H NMR, UV/Vis, and FTIR spectra; ESI-MS; and magnetic susceptibility. Electronic spectra and magnetic susceptibility of these Ru(II)/(III) complexes suggest that they are of a low spin crystal field split, where the Ru(III) is a d5 and Ru(II) d6 low spin. These compounds were tested for antibacterial activity on two bacterial species: Staphylococcus aureus (S. aureus) and Klebsiella pneumoniae (K. pneumoniae), as well as their drug-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) and multidrug resistant Klebsiella pneumoniae (MDR K. pneumoniae). All the compounds inhibited growth of the two non-drug-resistant bacteria and only one drug-resistant strain MRSA. However, only the ligands BUT and 2,2-dipyridylamine showed activity against MRSA, while all complexes did not show any antibacterial activity on MRSA. We observed large zones of inhibition for the Gram-positive S. aureus and MRSA bacteria, compared to the Gram-negative K. pneumoniae bacteria. DNA cleavage studies with gel electrophoresis showed denatured bacterial DNA on the gel from all the complexes, with the exception of the ligand, suggesting DNA nuclease activity of the complexes in the bacterial DNA. en_US
dc.description.sponsorship This work was financially supported by Botswana International University of Science and Technology Initiation Grants and University of Botswana Office of Research and Development. en_US
dc.language.iso en en_US
dc.publisher Hindawi Limited en_US
dc.subject 4-Cymene en_US
dc.subject Ruthenium en_US
dc.subject Iridium en_US
dc.title Synthesis of mixed ligand ruthenium (II/III) complexes and their antibacterial evaluation on drug-resistant bacterial organisms en_US
dc.description.level phd en_US
dc.description.accessibility unrestricted en_US
dc.description.department cfs en_US


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