An investigation was carried out to evaluate the isothermal oxidation behavior of nickel based superalloys at 1100 °C for 120 h. The alloys which were microstructured and nanostructured were developed by spark plasma sintering system. The oxidation test was carried out at a temperature of 1100 °C in air at different exposure time up to 120 h. The nanostructured nickel based alloy possessed better oxidation resistance with the formation of continuous adherent alumina, chromia scales, and spinel on the alloy surface and with no significant internal oxides. The oxidation rate of NiO was observed to be lower in the nanostructured nickel superalloy due to low diffusion rate of Nickel. The oxidation kinetics followed a parabolic oxidation law.